The term eczema is broadly applied to a range of persistent skin conditions. These include dryness and recurring skin rashes that are characterized by one or more of these symptoms: redness, skin swelling, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. Scratching open a healing lesion may result in scarring and may enlarge the rash. In some languages, dermatitis and eczema are synonyms, while in other languages dermatitis implies an acute condition and eczema a chronic one. Treatment is typically with moisturizers and steroid creams. Stem cells combined with PRP has shown efficacy in case where these are not effective. The disease was estimated as of 2010 to affect 230 million people globally.